For instance, the hub gene HIST1H1C was predicted to be regulated by TFs such as STAT1 and NFYA, and HIST1H1C has been reported to aggravate diabetic retinopathy by promoting inflammation, autophagy, glial activation and neuron loss [44], while STAT1 has been reported to be involved in AMD progression [45]; the hub gene TOP2B was predicted to be regulated by miR-568, miR-101, HDAC1 and others. The gene discussed is H1-2; the disease is age-related macular degeneration.