As shown in Fig. (12), all 7 hub genes, including TOP2B, SRRM2, HNRNPH1, HMGN2, HIST1H1C, SF3A1, and HIST1H2BD were down-regulated in AMD patients compared with control individuals, which suggested their potential value in AMD diagnosis. Here, SRRM2 is linked to age-related macular degeneration.