where a positive correlation between SESN2 levels and BMI, waist circumference, waist-to-hip ratio, and HOMA-IR was observed (13) but contrasts with some other studies where a negative correlation between SESN2 levels and markers of insulin resistance and adipogenicity in diabetic patients was found suggesting a protective role of SESN2 in diabetes (32). Here, SESN2 is linked to Insulin resistance.