Healthy individuals in the highest SESN2 tertile (T3) had significantly lower odds of high insulin (OR: 0.23, p < 0.01), high HbA1c (OR: 0.33, p < 0.01), high triglycerides (OR: 0.37, p = 0.03), high HOMA-IR (OR: 0.58, p = 0.06), high TyG x waist-to-hip ratio (OR: 0.39, p = 0.02), high VAI (OR: 0.46, p = 0.03), high LAP (OR: 0.49, p = 0.03), high AIP (OR: 0.42, p = 0.02) and the presence of MetS (OR: 0.23, p < 0.01). The gene discussed is INS; the disease is metabolic syndrome.