IL4 and pulmonary fibrosis: Reduced Treg cells in mice by intraperitoneal injection of appropriate amounts of CD25 antibody can attenuate the progression of silicosis mice (47) and radiation-induced pulmonary fibrosis (48), and further mechanistic experiments showed that the CD25 antibody could reduce the accumulation of fibroblasts to attenuate pulmonary fibrosis in mice by enhancing the Th17 cell response and altering IFN-γ, IL-12/IL-4, IL-5 secretion (48).