Wnt10b deficiency mice of allergic asthma results in enhanced memory T cell activation, increased Th2 polarization as evidenced by elevated IL-4 and IL-13 concentrations, and recombinant Wnt10b increases the percentage of naïve CD4+T and CD8+T cells in vitro, thereby mitigating allergic asthma (136). This evidence concerns the gene CD4 and allergic asthma.