The binding of CD27 on T cells to CD70 on fibroblasts can reduce fibroblast polarization and collagen deposition alleviate the process of pulmonary fibrosis; TCR and CD28 on T cells bind to MHC and CD80 respectively, thereby slowing down the process of pulmonary fibrosis; Ivacaftor binds to CFTR and HU-308 binds to CB2 alleviate the process of pulmonary fibrosis; SP100030 slows down pulmonary fibrosis by inhibiting the NF-κB signaling pathway and DHZ slows down pulmonary fibrosis by inhibiting the Wnt/β-catenin signaling pathway. Here, CD27 is linked to pulmonary fibrosis.