A similar phenomenon can be observed in BLM-induced IPF mice, where Th17 cells and their secreted IL-17 promote BLM-induced lung inflammation and fibrosis (37); the mechanism may be the IL-17 can mediate transforming growth factor β (TGF-β) signaling to promote Extracellular matrix (ECM) deposition (38). The gene discussed is IL17A; the disease is idiopathic pulmonary fibrosis.