Likewise, ACPA-positive RA among East Asian populations is associated with HLA-DRB1*04 SE alleles, showing a prominent effect of the *04:05 allele, with HLA-DRB1*10:01, and to a lesser degree with HLA-DRB1*01:01 (10–12). The gene discussed is HLA-DRB1; the disease is rheumatoid arthritis.