Moreover, STAT3 mutation has been investigated in EBV-positive inflammatory follicular dendritic cell sarcoma and EBV-positive HIV-associated diffuse large B-cell lymphoma (48, 49), and we believe that chronic active EBV infection may play an important role in the role of STAT3 mutation in activating tumor growth. This evidence concerns the gene STAT3 and Epstein-Barr virus infection.