Moreover, STAT3 mutation has been investigated in EBV-positive inflammatory follicular dendritic cell sarcoma and EBV-positive HIV-associated diffuse large B-cell lymphoma (48, 49), and we believe that chronic active EBV infection may play an important role in the role of STAT3 mutation in activating tumor growth. The gene discussed is STAT3; the disease is diffuse large B-cell lymphoma.