Individually, higher frequency of CD15+CD14+monocytes [0.83 (95%CI 0.71,0.94)], CD45RA-CX3CR1+CTLA4+CD4+ T cells [0.77 (95%CI 0.64,0.90)], CD45RA−17A+CD4+ T cells [0.76 (95% CI 0.61,0.90)], and Ki67+ B cells [0.76 (95%CI 0.64, 0.88)] yielded good AUROC for distinguishing sepsis from healthy. The gene discussed is CTLA4; the disease is Sepsis.