The mRNA expression levels of seven major genes in this pathway were verified by qPCR, and all of them were significantly down-regulated in SLE patients (Figure 6A), with SH2D1B, CD247, KLRC2 and KLRC3 being more pronounced in those with SLEDAI scores higher than 10 (Figure 6B). This evidence concerns the gene CD247 and systemic lupus erythematosus.