The mRNA expression levels of seven major genes in this pathway were verified by qPCR, and all of them were significantly down-regulated in SLE patients (Figure 6A), with SH2D1B, CD247, KLRC2 and KLRC3 being more pronounced in those with SLEDAI scores higher than 10 (Figure 6B). The gene discussed is SH2D1B; the disease is systemic lupus erythematosus.