However, COL3A1 may have a negative impact on the prognosis of adrenocortical carcinoma (ACC), KICH, kidney renal clear cell carcinoma (KIRC), kidney renal papillary cell carcinoma (KIRP), brain lower grade glioma (LGG), etc. FBLN1 appeared to be a risk factor for thyroid carcinoma (THCA) and a protective factor for uveal melanoma (UVM). This evidence concerns the gene COL3A1 and uveal melanoma.