Building on this discovery, MR analysis employing 33 CRPGs further confirmed the tumor-suppressive role of TNNC1. The analysis revealed that increased TNNC1 expression significantly reduces the risk of LUAD (OR = 0.737; 95% CI, 0.550–0.988; P = 0.041) (Supplementary Figure S2A). Here, TNNC1 is linked to neoplasm.