CXCL8 and neoplasm: In this regard, ITF3756 downregulated the expression of CCL2 and CXCL8, which are two chemokines related to monocytes activation but also reported to be secreted by tumor infiltrating monocytes and TAMs, and promoting tumor growth and an immunosuppressive tumor environment, directly affecting tumor cells or recruiting pro-tumorigenic immune cells in TME (46–48).