When there is infection (osteomyelitis), a 2 stage approach is recommended: stage 1—remove infected implants, aggressively debride infected/avascular tissues, administer local (antibiotic impregnated calcium sulfate resorbable beads) and systemic antibiotics based on tissue-based culture and sensitivities; stage 2 (after definitive eradication of infection)—attain rigid interfragmentary mechanical stabilization ± bone grafting (autogenous cancellous bone) ± fracture repair enhancers (electrical stimulation, low-intensity pulsed ultrasound, demineralized bone matrix, biologics-BMP-2). This evidence concerns the gene BMP2 and infection.