The plasma MDA levels in MDM2 unmethylated group were significantly higher than those in MDM2 methylated group, however, SOD, GSH, NRF2, HO-1, and GPX4 levels were significantly decreased in plasma of the unmethylated group compare with the methylated group in the HBV-related HCC patients. The gene discussed is HMOX1; the disease is hepatocellular carcinoma.