HMOX1 and hepatocellular carcinoma: Moreover, the levels of SOD, GSH, NRF2, HO-1, and GPX4 were decreased in MDM2 unmethylated group compared with MDM2 methylated group in the plasma of the HBV-related HCC patients (SOD: p < 0.0001; GSH: p = 0.003; NRF2: p = 0.0002; HO-1: p = 0.017; GPX4: p = 0.006) (Figures 3H,J–M).