NR2C2AP and cancer: Interestingly, genes upregulated in TRA16-positive cancer cells were enriched for several key biological processes, including SRP-dependent cotranslational protein targeting to the membrane, cotranslational protein targeting to the membrane, protein targeting to the endoplasmic reticulum (ER), establishment of protein localization to the ER, protein targeting to the membrane, and translational initiation (Figure 2C).