Ferroptosis, characterized by iron-dependent lipid peroxidation, has emerged as an essential mechanism in various pathological conditions (Liu et al., 2023; Martin-Sanchez et al., 2020; Xu et al., 2021; Yao et al., 2021; Zhang et al., 2022), including CYP-induced cystitis, as recently reported by our group (Mao et al., 2023a). Here, PPIG is linked to chronic cystitis.