In particular, levels of Angiopoietin-2 (Ang2) are dramatically elevated in cardiovascular and cerebrovascular diseases, such as coronary heart disease (Wu et al., 2016) and stroke (Liu et al., 2009), with disease severity positively correlated with increased Ang2 levels (Chen et al., 2020; Peplinski et al., 2021). The gene discussed is ANGPT2; the disease is cerebrovascular disorder.