Apoptosis is the core mechanism of action for anti-tumor drugs, and its regulation depends on the balance between pro-apoptotic factors (Bax, Caspase-3) and anti-apoptotic factors (Bcl-2) (Zhang et al., 2019; Choudhary et al., 2019; Carmeliet, 2015). Here, BCL2 is linked to neoplasm.