In OLP activated cytotoxic (CD8+) T-lymphocytes are thought to interact with other inflammatory cells such as helper (CD4+) subpopulations, Langerhans cells (CD1a+), and MΦ (CD68+), as well as basal keratinocytes, leading ultimately to keratinocyte apoptosis (77). The gene discussed is CD8A; the disease is oral lichen planus.