The importance of the ITGB2 pathway in MΦ function is emphasized by a positive correlation between ITGB2 expression and CD163+ MΦ infiltration in esophageal carcinoma where scRNA-seq analysis indicated a progressive increase in ITGB2 with the acquisition of a tumor-promoting phenotype (81). The gene discussed is ITGB2; the disease is carcinoma of esophagus.