While the majority of cases are primarily attributed to gallstones and alcohol consumption, hypertriglyceridemia (HTG) is considered the third most common cause of AP, accounting for 4-10 % of severe AP admissions worldwide [1,2]. Hypertriglyceridemic pancreatitis (HTGP) occurs when excess chylomicrons are hydrolyzed by pancreatic lipase, releasing free fatty acids (FFAs) that cause microvascular injury and acidosis, precipitating pancreatic inflammation. The gene discussed is PNLIP; the disease is alkaline phosphatase measurement.