IHC markers such as CD20, CD10, BCL6, MUM1, BCL2, and MIB-1 play a crucial role in differentiating DLBCL from other B-cell lymphomas [6] and distinguishing it from conditions such as plasmablastic lymphoma (PBL) or Burkitt lymphoma, which are also seen in HIV-associated lymphoproliferative disorders. The gene discussed is BCL6; the disease is diffuse large B-cell lymphoma.