Recently, it was reported that the ClyA and FlaB secreted by Salmonella typhimurium could remodel the tumor immune microenvironment to carry out the strong anti‐tumor effect.[19] Jean et al. engineered an arabinose‐induced E. coli strain to express toxic proteins Staphylococcus aureus α‐hemolysin (SAH), which could reduce 91% of the 4T1 tumor volume.[20] SAH is a naturally secreted pore‐forming protein that can induce mammalian cell lysis. Here, ACSM3 is linked to neoplasm.