The interaction between environmental factors and the polygenic genetic background of susceptible hosts can affect the disease phenotype and progression.[16]PNPLA3 has been identified as a major common genetic determinant of NAFLD, and TM6SF2, MBOAT7, and GCKR have been shown to contribute significantly.[17] Combining clinical and genetic indicators may be an effective way to improve NIT efficiency. Here, GCKR is linked to metabolic dysfunction-associated steatotic liver disease.