Later, in 2014, Li et al. documented specific antibodies against receptors in the autonomic nervous system in POTS patients, specifically autoantibodies against adrenergic alpha-1 receptors (ADRA1) and autoantibodies against beta-1 (ADRB1) and beta-2 adrenergic receptors (ADRB2) [10]. The gene discussed is ADRB1; the disease is postural orthostatic tachycardia syndrome.