Obesity-induced chronic inflammation triggers elevations in white blood cell (WBC) and monocyte (MO) counts, high-sensitivity C-reactive protein (hs-CRP), and inflammatory cytokines such as interleukin 1β (IL-1β), IL-6, and tumor necrosis factor α (TNFα). The gene discussed is TNF; the disease is obesity due to melanocortin 4 receptor deficiency.