For example, the intact cag PAI strain induces overexpression of pro-cancer miR-21 and down-regulation of tumor suppressor miR-34a through CagA, promoting abnormal cell signaling pathways and uncontrolled proliferation, continuously activating the NF-κB pathway, and promoting tumor migration, invasion, and microenvironment remodeling [28,39]. Here, S100A8 is linked to neoplasm.