Vaccination with a pool of only IFN-γ- or IL-10-selective epitopes or with a pool of both types of epitopes targeting IGFBP-2 in a mouse model of breast cancer or PSMA in a mouse model of prostate cancer revealed that it is essential for the IL-10 selective epitopes to be edited out of a polyepitope vaccine. The gene discussed is IFNG; the disease is breast cancer.