A considerable number of publications have reported an association of the T2-high asthma endotype with a number of clinical features, particularly high serum levels of total IgE, sensitization to aeroallergens allergens, elevated blood and sputum eosinophil levels, as well as the presence of concomitant diseases, such as atopic dermatitis and allergic rhinitis. Here, IGHE is linked to atopic eczema.