IGHE and allergic disease: Allergic disorders are typically characterized by aberrant generation of Th2-polarized immune responses indicated by the induction of allergen-specific IgE and Th2-type cytokines (IL-14, IL-5, IL-13, etc.)secreting T cells that collaboratively lead to activation of effector cells such as basophils and mast cells, which play a critical role in mediating and exaggerating allergic reactions [4].