Among these, IL-6 is a pleiotropic cytokine whose involvement in the acute phase response enhances the early host immune response to M. tb, particularly by promoting T-cell activation and Th17-cell differentiation and assisting in the formation of more effective granulomas to limit the spread of M. tb, suggesting that IL-6 may be beneficial to some extent for anti-TB protection [59]. The gene discussed is IL6; the disease is tuberculosis.