Chronic infection with Schistosoma mansoni also induces a type 2 immune response characterized by elevated interleukin-10 (IL-10) production, which modulates both type 1 and type 2 immune responses, reducing the risk of autoimmune diseases like multiple sclerosis, diabetes, and Crohn’s disease, as well as allergic conditions such as asthma [98,99,100]. This evidence concerns the gene IL10 and Crohn disease.