Interestingly, TRIM25 can mediate breast cancer cell autophagy via UBC12-enhanced TRIM25 neddylation, which increases transcription factor EB (TFEB) K63-linked polyubiquitination and nuclear translocation and thus activates autophagy-related gene expression, leading to drug resistance [17,58] (Figure 2(Bd)). The gene discussed is TRIM25; the disease is breast cancer.