As SARS-CoV and SARS-CoV-2 infection is postulated to cause pulmonary inflammation in part by causing ACE2 downregulation, IFNβ-ACE2 may prevent inflammatory lung diseases in infected patients by blocking ACE2 downregulation and augmenting anti-inflammatory sACE2 concentrations [31,33,35,37,61]. This evidence concerns the gene IFNB1 and inflammatory response.