The distinction of nucleocapsid+ versus nucleocapsid- subsets as infected versus uninfected subsets was validated in that the nucleocapsid+ subset corresponded to an ACE2low and TMPRSS2low phenotype, and vice versa, which corresponds with the downregulation of the ACE2 host receptor and the TMPRSS2 coreceptor upon infection (Figure 3D–M). The gene discussed is ACE2; the disease is infection.