ACE2 and infection: The main advantage of the IFNβ-ACE2 fusion protein is that the physical linkage of sACE2 and IFN-β provides synergistic benefits because the virus/IFNβ-ACE2 complex creates an IFN-β array at the viral surface such that robust IFN-β signaling and upregulation of antiviral innate defenses invariably precede cellular infection (Figure 1).