On the other hand, using C57BL/6J mice Aldridge et al. (2009) [56] showed that during lethal infections with influenza viruses H1N1 A/PuertoRico/8/34 and H5N1 A/Vietnam/1203/2004, a specific subset of TNFα/inducible nitric oxide synthase (iNOS)-producing DCs (tipDCs) accumulate significantly in the lung. The gene discussed is NOS2; the disease is infection.