One of the most significant observations in LC4 cells is their ability to model the immune-suppressive environment found within the parental tumor, mainly through the downregulation of B2M, a critical component of the MHC Class I antigen presentation pathway, and the inhibition of IKZF1, a transcription factor involved in lymphocyte recruitment, highlighting key mechanisms of immune evasion. This evidence concerns the gene IKZF1 and neoplasm.