As shown in Figure 3B, the top 20 most significantly enriched signaling pathways included DNA replication, the TNF signaling pathway, the NF-κB signaling pathway, cellular senescence, endocrine resistance, chronic myeloid leukemia, and T-cell leukemia virus type 1 infection. Here, TNF is linked to chronic myelogenous leukemia, BCR-ABL1 positive.