Notably, differential ACE2 cleavage mediated by ADAM17/TMPRSS2 may have a significant impact on the pathophysiology of COVID-19, since TMPRSS2-mediated ACE2 cleavage does not enhance ACE2 shedding from the cell surface, inhibiting the shedding process mediated by ADAM17 [40,41]. The gene discussed is ACE2; the disease is COVID-19.