Indeed, distinct immunological signatures in LC patients with pulmonary or neurological symptoms are characterized by the higher production of inflammatory cytokines, mainly IL-6, TNF-α, and IL-1β, along with a reduced CD8+ T cell activation diversity and exhaustion markers expression (PD-1 and CTLA-4, respectively) in SARS-CoV-2 spike-specific CD4+T cells [88,89,90,91]. This evidence concerns the gene CD8A and laryngotracheoesophageal cleft.