The mechanisms by which obesity induces endometrial cancer are described as follows: the conversion of androstenedione, an androgen, to estrone, with a decreased serum level of sex-hormone binding globulin (SHBG) will create an environment enriched in estrogen and thus stimulate the development of endometrial cancer cells [15]. The gene discussed is SHBG; the disease is obesity due to melanocortin 4 receptor deficiency.