Importantly, recent data indicate that autophagy facilitates lipid peroxide accumulation by promoting GPX4 degradation [48], For example, chaperone-mediated autophagy of GPX4 promotes ferroptosis in renal tubules during acute kidney injury (AKI) [49], a mechanism confirmed in several ferroptosis-related pathological models [50,51]. This evidence concerns the gene GPX4 and acute kidney injury.