Genetic factors such as the concentration of specific alleles resulting from consanguineous crosses, such as the ADAMTS20 and DLX6 genes, are some genes shared between dogs and humans that increase the incidence of cleft palate in dogs [4,5], and/or dysfunctions of the regulators and migrators of mesoderm and neural crest cells. The gene discussed is ADAMTS20; the disease is cleft palate.