In the published studies, curcumin could attenuate muscle protein breakdown by activating histone deacetylase sirtuin-1, which lessened muscular atrophy in mice [18]; quercetin exhibited protective effects against obesity-associated skeletal muscle atrophy by inhibiting the inflammatory receptor Toll-like receptor 4 (TLR4) in mice [19]. The gene discussed is TLR4; the disease is obesity due to melanocortin 4 receptor deficiency.