SV2A and Seizure: Levetiracetam’s modulation of SV2A may help restore the balance between excitatory and inhibitory neurotransmission, such as the glutamatergic and GABAergic systems, respectively, through alteration of the presynaptic release of glutamate (reducing) and GABA (increasing), leading to decrease in both hyperexcitability and, therefore, epileptic seizures [1,4,6,7].