A group of AA including leucine (Leu), isoleucine (Ile), valine (Val), lysine (Lys), arginine (Arg), threonine (Thr), phenylalanine (Phe), and alanine (Ala) have been linked to a rapid increase in insulin secretion leading to hyperinsulinemia, which could eventually increase the risk of insulin resistance [21,22,23,24,25,26,27]. Here, INS is linked to Insulin resistance.