When further adjusted for age; sex; type of MI; hypertension; diabetes mellitus; old MI; previous PCI and CABG; smoking and alcohol consumption; creatinine, triglyceride, HDL-C, LDL-C, and peak cardiac troponin I levels; LVEF; number of diseased vessels; emergency PCI; elective PCI; and medications (model 1), the risks of MACE, cardiac death, and recurrent MI were increased by 28% (HR 1.28, 95% CI 1.10–1.49), 44% (HR 1.44, 95% CI 1.12–1.84), and 27% (HR 1.27, 95% CI 1.04–1.55), respectively, per one increment in ln-transformed TMAO. This evidence concerns the gene TNNI3 and myocardial infarction.