At a dose of 50 mg/kg/day, DCI reduced body weight in the mice, improved insulin resistance, and reduced levels of cytosolic phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G6Pase), key enzymes in gluconeogenesis, besides reducing lipid accumulation in the liver. This evidence concerns the gene G6PC1 and Insulin resistance.