A recent longitudinal, randomized, double-blind clinical trial conducted in 133 hyperinsulinemic obese children and adolescents showed that the administration of three tablets (2175 mg/day) of PGR before the two main meals for one year, in addition to a low glycemic index diet, led to a 22.4% reduction in BMI, decreased glycated hemoglobin (HbA1c) levels and acanthosis nigricans, and improved glucose metabolism and insulin sensitivity among children [29]. The gene discussed is INS; the disease is acanthosis nigricans.