IL6 and periodontitis: In an observational clinical trial by Berlutti F. et al. [39] involving the topical administration of bovine lactoferrin (bLf) to volunteers with periodontitis, bLf was shown to reduce cytokine levels, including IL-6 in crevicular fluid, as well as edema, bleeding, pocket depth, and both gingival and plaque indexes, leading to improved clinical attachment levels.