Co-infection of SCoV2 with H3N2 (OK/483) led to enhanced levels of IFNs, IP-10, ISG15, and MDA5 than that by SCoV2 infection while H1N1 co-infection enhanced IP-10, ISG15, and MDA5 compared with SCoV2 single infection (Figure 7). The gene discussed is ISG15; the disease is infection.