CASP1 and autosomal dominant cutis laxa: Moreover, a strong positive correlation was observed between CASP1 and CASP5 in ADCL, and between CASP1 and GSDMD in MCL, indicating that in the hyporeactive clinical form (ADCL), inflammasomes are activated by both canonical and non-canonical pathways, whereas in MCL, the main activation occurs via the canonical pathway.