HIF1A and neoplasm: Although the expression of HIF-1α in tumors was significantly reduced 6.22 ± 4.09 pg/mL/mg in the ONB group compared to the NB group 24 h after the first treatment, the destructive, hemorrhagic, and necrotic tumor microenvironment after anti-vascular effect inhibit the efficiency of ONB and oxygen delivery in the subsequent treatments.