Selenium nanoparticles (SeNPs) combined with p-coumaric acid have also exhibited therapeutic efficacy for inflammatory disorders such as acute gouty arthritis in RA rat models by increasing CAT and glutathione peroxidase (GPx1) mRNA levels while decreasing the mRNA levels of cyclooxygenase-2 (COX-2) [115]. Here, PTGS2 is linked to rheumatoid arthritis.