It also aids in folding of STAT3 [10] and huntingtin (Htt) [11] and is linked to various proteins and pathways, including MYC, CCDN1 [12], PP2A [13], Wnt7b/β-catenin, P53 [14], AKT/mTOR [4], and the AML1-ETO fusion protein in M2-type AML [15,16]. The gene discussed is RUNX1; the disease is acute myeloid leukemia.